New Preprints
Fanchong Jian†, Anna Z. Wec†, Leilei Feng†, Yuanling Yu, Lei Wang, Peng Wang, Lingling Yu, Jing Wang, Jacob Hou, Daniela M. Berrueta, Diana Lee, Tessa Speidel, LingZhi Ma, Thu Kim, Ayijiang Yisimayi, Weiliang Song, Jing Wang, Lu Liu, Sijie Yang, Xiao Niu, Tianhe Xiao, Ran An, Yao Wang, Fei Shao, Youchun Wang, Simone Pecetta, Xiangxi Wang*, Laura M. Walker*, Yunlong Cao*A generalized framework to identify SARS-CoV-2 broadly neutralizing antibodiesbioRxiv 2024[Link][PDF]
Selected Publications
Fanchong Jian†, Jing Wang†, Ayijiang Yisimayi†, Weiliang Song†, Yanli Xu†, Xiaosu Chen, Xiao Niu, Sijie Yang, Yuanling Yu, Peng Wang, Haiyan Sun, Lingling Yu, Jing Wang, Yao Wang, Ran An, Wenjing Wang, Miaomiao Ma, Tianhe Xiao, Qingqing Gu, Fei Shao, Youchun Wang, Zhongyang Shen, Ronghua Jin, Yunlong Cao*Evolving antibody response to SARS-CoV-2 antigenic shift from XBB to JN.1Nature 2024[Link][PDF]
Ayijiang Yisimayi†, Weiliang Song†, Jing Wang†, Fanchong Jian†, Yuanling Yu†, Xiaosu Chen†, Yanli Xu, Sijie Yang, Xiao Niu, Tianhe Xiao, Jing Wang, Lijuan Zhao, Haiyan Sun, Ran An, Na Zhang, Yao Wang, Peng Wang, Lingling Yu, Zhe Lv, Qingqing Gu, Fei Shao, Ronghua Jin, Zhongyang Shen, Xiaoliang Sunney Xie, Youchun Wang, Yunlong Cao*Repeated Omicron exposures override ancestral SARS-CoV-2 immune imprintingNature 2024[Link][PDF]
Sijie Yang†, Yuanling Yu†, Yanli Xu, Fanchong Jian, Weiliang Song, Ayijiang Yisimayi, Peng Wang, Jing Wang, Jingyi Liu, Lingling Yu, Xiao Niu, Jing Wang, Yao Wang, Fei Shao, Ronghua Jin, Youchun Wang, Yunlong Cao*Fast evolution of SARS-CoV-2 BA.2.86 to JN.1 under heavy immune pressureLancet Infectious Diseases 2023[Link][PDF]
Can Yue†, Weiliang Song†, Lei Wang, Fanchong Jian, Xiaosu Chen, Fei Gao, Zhongyang Shen, Youchun Wang, Xiangxi Wang*, Yunlong Cao*ACE2 binding and antibody evasion in enhanced transmissibility of XBB.1.5Lancet Infectious Diseases 2023[Link][PDF]
Yunlong Cao†*, Fanchong Jian†, Jing Wang†, Yuanling Yu†, Weiliang Song†, Ayijiang Yisimayi, Jing Wang, Ran An, Xiaosu Chen, Na Zhang, Yao Wang, Peng Wang, Lijuan Zhao, Haiyan Sun, Lingling Yu, Sijie Yang, Xiao Niu, Tianhe Xiao, Qingqing Gu, Fei Shao, Xiaohua Hao, Yanli Xu, Ronghua Jin, Zhongyang Shen, Youchun Wang*, Xiaoliang Sunney Xie*Imprinted SARS-CoV-2 humoral immunity induces convergent Omicron RBD evolutionNature 2023[Link][PDF]
Yunlong Cao†*, Fanchong Jian†, Zhiying Zhang†, Ayijiang Yisimayi†, Xiaohua Hao†, Linlin Bao†, Fei Yuan, Yuanling Yu, Shuo Du, Jing Wang, Tianhe Xiao, Weiliang Song, Ying Zhang, Pulan Liu, Ran An, Peng Wang, Yao Wang, Sijie Yang, Xiao Niu, Yuhang Zhang, Qingqing Gu, Fei Shao, Yaling Hu, Weidong Yin, Aihua Zheng, Youchun Wang, Chuan Qin*, Ronghua Jin*, Junyu Xiao*, Xiaoliang Sunney Xie*Rational identification of potent and broad sarbecovirus-neutralizing antibody cocktails from SARS convalescentsCell Reports 2022[Link][PDF]
Yunlong Cao†*, Ayijiang Yisimayi†, Fanchong Jian†, Weiliang Song†, Tianhe Xiao†, Lei Wang†, Shuo Du†, Jing Wang†, Qianqian Li†, Xiaosu Chen†, Yuanling Yu†, Peng Wang, Zhiying Zhang, Pulan Liu, Ran An, Xiaohua Hao, Yao Wang, Jing Wang, Rui Feng, Haiyan Sun, Lijuan Zhao, Wen Zhang, Dong Zhao, Jiang Zheng, Lingling Yu, Can Li, Na Zhang, Rui Wang, Xiao Niu, Sijie Yang, Xuetao Song, Yangyang Chai, Ye Hu, Yansong Shi, Linlin Zheng, Zhiqiang Li, Qingqing Gu, Fei Shao, Weijin Huang, Ronghua Jin, Zhongyang Shen*, Youchun Wang*, Xiangxi Wang*, Junyu Xiao*, Xiaoliang Sunney Xie*BA.2.12.1, BA.4 and BA.5 escape antibodies elicited by Omicron infectionNature 2022[Link][PDF]
Yunlong Cao†*, Jing Wang†, Fanchong Jian†, Tianhe Xiao†, Weiliang Song†, Ayijiang Yisimayi†, Weijin Huang†, Qianqian Li, Peng Wang, Ran An, Jing Wang, Yao Wang, Xiao Niu, Sijie Yang, Hui Liang, Haiyan Sun, Tao Li, Yuanling Yu, Qianqian Cui, Shuo Liu, Xiaodong Yang, Shuo Du, Zhiying Zhang, Xiaohua Hao, Fei Shao, Ronghua Jin, Xiangxi Wang*, Junyu Xiao*, Youchun Wang*, Xiaoliang Sunney Xie*Omicron escapes the majority of existing SARS-CoV-2 neutralizing antibodiesNature 2022[Link][PDF]
Yunlong Cao†, Bin Su†, Xianghua Guo†, Wenjie Sun†, Yongqiang Deng†, Linlin Bao†, Qinyu Zhu†, Xu Zhang, Yinghui Zheng, Chenyang Geng, Xiaoran Chai, Runsheng He, Xiaofeng Li, Qi Lv, Hua Zhu, Wei Deng, Yanfeng Xu, Yanjun Wang, Luxin Qiao, Yafang Tan, Liyang Song, Guopeng Wang, Xiaoxia Du, Ning Gao, Jiangning Liu, Junyu Xiao, Xiao-dong Su, Zongmin Du, Yingmei Feng, Chuan Qin*, Chengfeng Qin*, Ronghua Jin*, Xiaoliang Sunney Xie*Potent neutralizing antibodies against SARS-CoV-2 identified by high-throughput single-cell sequencing of convalescent patients' B cellsCell 2020[Link][PDF]
Full Publications
- 2024
- 2023
- 2022
- 2021
- 2020
Leilei Feng†, Zhaoxi Sun†, Yuchen Zhang†, Fanchong Jian, Sijie Yang, Keely Xia, Lingling Yu, Jing Wang, Fei Shao, Xiangxi Wang*, Yunlong Cao*Structural and molecular basis of the epistasis effect in enhanced affinity between SARS-CoV-2 KP.3 and ACE2Cell Discovery 2024[Link][PDF]
Jingyi Liu†, Yuanling Yu†, Fanchong Jian, Sijie Yang, Weiliang Song, Peng Wang, Lingling Yu, Fei Shao, Yunlong Cao*Enhanced immune evasion of SARS-CoV-2 variants KP.3.1.1 and XEC through N-terminal domain mutationsLancet Infectious Diseases 2024[Link][PDF]
Fanchong Jian†, Jing Wang†, Ayijiang Yisimayi†, Weiliang Song†, Yanli Xu†, Xiaosu Chen, Xiao Niu, Sijie Yang, Yuanling Yu, Peng Wang, Haiyan Sun, Lingling Yu, Jing Wang, Yao Wang, Ran An, Wenjing Wang, Miaomiao Ma, Tianhe Xiao, Qingqing Gu, Fei Shao, Youchun Wang, Zhongyang Shen, Ronghua Jin, Yunlong Cao*Evolving antibody response to SARS-CoV-2 antigenic shift from XBB to JN.1Nature 2024[Link][PDF]
Xiao Niu†, Zhiqiang Li†, Jing Wang†, Fanchong Jian, Yuanling Yu, Weiliang Song, Ayijiang Yisimayi, Shuo Du, Zhiying Zhang, Qianran Wang, Jing Wang, Ran An, Yao Wang, Peng Wang, Haiyan Sun, Lingling Yu, Sijie Yang, Tianhe Xiao, Qingqing Gu, Fei Shao, Youchun Wang, Junyu Xiao*, Yunlong Cao*Omicron-specific ultra-potent SARS-CoV-2 neutralizing antibodies targeting the N1/N2 loop of Spike N-terminal domainEmerging Microbes & Infections 2024[Link][PDF]
Ayijiang Yisimayi, Weiliang Song, Jing Wang, Fanchong Jian, Yuanling Yu, Xiaosu Chen, Yanli Xu, Ran An, Yao Wang, Jing Wang, Haiyan Sun, Peng Wang, Lingling Yu, Fei Shao, Ronghua Jin, Zhongyang Shen, Youchun Wang, Yunlong Cao*Prolonged Omicron-specific B cell maturation alleviates immune imprinting induced by SARS-CoV-2 inactivated vaccineEmerging Microbes & Infections 2024[Link][PDF]
Can Yue†, Shuo Liu†, Bo Meng†*, Kaiyue Fan†, Sijie Yang†, Pan Liu, Qianhui Zhu, Xin Mao, Yuanling Yu, Fei Shao, Peng Wang, Youchun Wang*, Ravindra Kumar Gupta*, Yunlong Cao*, Xiangxi Wang*Deletion of V483 in the spike confers evolutionary advantage on SARS-CoV-2 for human adaptation and host-range expansion after a prolonged pandemicCell Research 2024[Link][PDF]
Pan Liu†, Can Yue†, Bo Meng†, Tianhe Xiao†, Sijie Yang†, Shuo Liu†, Fanchong Jian, Qianhui Zhu, Yuanling Yu, Yanyan Ren, Peng Wang, Yixin Li, Jinyue Wang, Xin Mao, Fei Shao, Youchun Wang*, Ravindra Kumar Gupta*, Yunlong Cao*, Xiangxi Wang*Spike N354 glycosylation augments SARS-CoV-2 fitness for human adaptation through structural plasticityNational Science Review 2024[Link][PDF]
Wentai Ma†, Haoyi Fu†, Fanchong Jian, Yunlong Cao, Mingkun Li*Distinct SARS-CoV-2 populational immune backgrounds tolerate divergent RBD evolutionary preferencesNational Science Review 2024[Link][PDF]
Sijie Yang†, Yuanling Yu†, Fanchong Jian, Ayijiang Yisimayi, Weiliang Song, Jingyi Liu, Peng Wang, Yanli Xu, Jing Wang, Xiao Niu, Lingling Yu, Yao Wang, Fei Shao, Ronghua Jin, Youchun Wang, Yunlong Cao*Antigenicity assessment of SARS-CoV-2 saltation variant BA.2.87.1Emerging Microbes & Infections 2024[Link][PDF]
Ayijiang Yisimayi†, Weiliang Song†, Jing Wang†, Fanchong Jian†, Yuanling Yu†, Xiaosu Chen†, Yanli Xu, Sijie Yang, Xiao Niu, Tianhe Xiao, Jing Wang, Lijuan Zhao, Haiyan Sun, Ran An, Na Zhang, Yao Wang, Peng Wang, Lingling Yu, Zhe Lv, Qingqing Gu, Fei Shao, Ronghua Jin, Zhongyang Shen, Xiaoliang Sunney Xie, Youchun Wang, Yunlong Cao*Repeated Omicron exposures override ancestral SARS-CoV-2 immune imprintingNature 2024[Link][PDF]