A model to explain the exceptional immune imprinting in mRNA-vaccinated human
Jian et al. Nature 2024
Repeated Omicron exposures override ancestral SARS-CoV-2 immune imprinting
Yisimayi et al. Nature 2024
Predicting the evolution of SARS-CoV-2 Omicron RBD
Cao et al. Nature 2023
High-throughput deep mutational scanning and epitope mapping
Cao et al. Nature 2022
Humoral immune evasion hotspots on SARS-CoV-2 RBD
Cao et al. Nature 2022
Identify neutralizing antibodies by high-throughput scVDJ-seq
Cao et al. Cell 2020Cao Lab investigates humoral immunity and antibodies at single-cell and molecular level. Our research interests include the following aspects:
- Antibody response, immune escape and immune imprinting in infectious diseases
- Development of broad-spectrum antibody therapeutics and vaccines
- Deciphering the relationship between targeting epitopes and functions of antibodies for various antigens
- Computational and machine learning methods for modeling antibody-antigen interaction
|2025-01-08