Identify neutralizing antibodies by high-throughput scVDJ-seq Cao et al. Cell 2020
Humoral immune evasion hotspots on SARS-CoV-2 RBD Cao et al. Nature 2022
High-throughput deep mutational scanning and epitope mapping Cao et al. Nature 2022
Predicting the evolution of SARS-CoV-2 Omicron RBD Cao et al. Nature 2023
Repeated Omicron exposures override ancestral SARS-CoV-2 immune imprinting Yisimayi et al. Nature 2024
Cao Lab investigates humoral immunity and antibodies at single-cell and molecular level. Our research interests include the following aspects:
Antibody response, immune escape and immune imprinting in infectious diseases including SARS-CoV-2
Development of antibody therapeutics and vaccines
Deciphering the relationship between targeting epitopes and functions of antibodies for various antigens
Computational and machine learning methods for modeling antibody-antigen interaction
